This study of the ipecacuanha root and its effects as a emetic, nauseant, expectorant and dispahoretic, Leibniz issued on what he called "the new American antidysentery drug" after reading about the root in Piso and Marggraf's Historia naturalis Brasilia (1648). The report is considered Leibniz's most comprehensive contribution to medicine. The printer of the work, Freytag, issued it in three different ways: As an appendix to Freytag's edition of Martin Lister's Sex exercitationes medicales de quibusdam morbis chronicis (Frankfurt, 1696), and also in Freytag's early periodical, Miscellanea curiosa, sive Ephemeridum medico-physicarum Germanicarum (Nuremberg, 1696). From that publication a separate pamphlet, or an early journal offprint, was also issued.