An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16061 entries, 14144 authors and 1947 subjects. Updated: December 10, 2024

Permanent Link for Entry #16568

  • 14249

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. II. Reconstitution of functional rough microsomes from heterologous components.

J. Cell Biol., 67, 835-851; 852-862, 1975.

"In 1975 Günther Blobel showed that in certain cases amino acids in a protein serve as an address label that determines where a protein is to be delivered. Amino acid sequences determine whether a protein is to be passed through the membrane out of the cell or into an organelle or is to be built in the membrane." (Nobel website).

In 1999 Günter Blobel was awarded the Nobel Prize in Physiology or Medicine "for the discovery that proteins have intrinsic signals that govern their transport and localization in the cell."

See also: Simon, Sanford M. and Blobel, "A protein-conducting channel in the endoplasmic reticulum," Cell, 65, 1991, 371-380.
See also: Sanford M. Simon, "Obituary: Günther Blobel (1936-2018)," Cell, 173, 2018, 278-280. Available from PubMedCentral at this link.



Subjects: BIOLOGY › Cell Biology, NOBEL PRIZES › Nobel Prize in Physiology or Medicine
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