An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”
Permanent Link for Entry #16588
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Enhancement of antitumor immunity by CTLA-4 blockade.Science, 271, 1734-1736, 1996.In the early 1990s James Allison showed that CTLA-4 acts as an inhibitory molecule to restrict T-cell responses. In 1996, Allison was the first to show that antibody blockade of a T-cell inhibitory molecule (known as CTLA-4) could lead to enhanced anti-tumor immune responses and tumor rejection. Order of authorship in the original publication: Leach, Krummel, Allison. Subjects: IMMUNOLOGY › Molecular Immunology, NOBEL PRIZES › Nobel Prize in Physiology or Medicine Permalink: garrison-morton.com/id/16588 |