An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”
Permanent Link for Entry #16660
|
Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission.New Eng. J. Med., 326, 90-94, 1992.Using strips of corpus cavernosum tissue from 21 male volunteers, the authors showed how the interaction of nitric oxide with the musculo/vascular system of the human penile corpora cavernosa initiated and maintained a penile erection. In this paper they used a drug designated ‘M&B 22948’ which is an inhibitor of cyclic guanosine monophosphate (GMP), to show that this drug has the same vasodilatory effect that nitric oxide has after its molecular interaction with the GMP/guanylate cyclase system on the penis. They determined that this drug was a ‘phosphodiesterase-5 (PD5), inhibitor’ and in doing so, they were the very first to observe the action of a PD5 inhibitor on the erection process. The discovery was commercialized with erection drugs such as Viagra and Cialis. Subjects: SEXUALITY / Sexology › Impotence, UROLOGY Permalink: garrison-morton.com/id/16660 |