Botulism first described. Kerner published an expanded study as Neue Beobachtungen über die in Würtemberg so häufig vorfallenden tödtlichen Vergiftung durch den Genuss geräuchter Würstem, Tübingen, 1820. He published his most extensive report as Das Fettgift oder Die Fettsäure und ihre Wirkungen auf den thierischen Organismus, ein Beitrag zur Untersuchung des in Würsten giftig wirkenden Stoffes (1822). This monograph "reviewed 155 cases of poisoned patients and precisely described the autonomic dysfunctions: “The tear fluid disappears, the gullet becomes a dead and motionless tube; in all mucous cavities of the human machine the secretion of the normal mucus stands still, from the largest, the stomach, to the tear duct and the excretory ducts of the lingual glands. No saliva is secreted. No drop of wetness is felt in the mouth…”. (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(05)78793-6/fulltext).