Houssay’s depancreatized hypophysectomized dog. This work led to Houssay’s demonstration of the importance of the anterior pituitary in sugar metabolism. See also Endocrinology, 1931,15, 511-23.

In 1947 Houssay shared the Nobel Prize in Physiology or Medicine "for discovery of the part played by the hormone of the anterior pituitary lobe in the metabolism of sugar."

Houssay and Fasciolo transplanted an ischemic kidney into an animal from which both kidneys had been removed. Hypertension resulted after establishment of circulation, supporting the view that hypertension is due to a chemical substance with pressor action produced in the ischemic kidney. They later showed that the ischemic kidneys of hypertensive dogs contained an excess of renin. See also Biol. Acad. nac. Med. B. Aires, 1937, 34, 342; J. Physiol. (Lond.), 1938, 94, 281.