Economo’s classic description of epidemic encephalitis (“von Economo’s disease”) was published on 10 May 1917; see No. 4649.

This work consisted of textbook of more than 800 pages and an atlas with 112 large-sized microphotographic plates of the cortex. The textbook contained detailed descriptions of their studies and an introduction to the history of cytoarchitectonic research. With their atlas, von Economo and Koskinas hoped to create a basis for future brain research and the localization of brain functions since they assumed that cytoarchitectonic differences reflect functional differences. They used letters to categorize the architecture, e.g., "F" for areas of the frontal lobe.

"The exceptionally high-resolution photographs of the human cerebral cortex presented here are a unique and lasting contribution to neuroanatomy" (Larry W. Swanson). In their chapter on the microscopic structure of the cerebral cortex, Clarke and O’Malley (1996) wrote that, “C. von Economo and G.N. Koskinas produced a monumental work on cortical areas (Die Cytoarchitektonik…), based on the work of Brodmann but identifying more than twice his number of areas [107]; it helped to dispel some of the confusion produced by the Vogt’s multiplicity of areas.” (p. 456). Abridged English translation, 1929. Complete English translation, edited, and published in large folio format, with additional appendix material and the plates reproduced full size as Atlas of cytoarchitectonics of the adult human cerbral cortex by Lazaros C. Triarhou (Basel: Karger, 2008).

Translated and adapted by K. O. Newman as Encephalitis lethargica its sequelae and treatment. London: Oxford University Press, 1931.