"Pregnancy is a life-threatening event in many parts of the developing world. Globally, it is estimated that 289,000 women died from being pregnant in 2013. The lifetime risk for dying as a result of pregnancy is as high as 1 in 6 for women living in the poorest nations of the world. Ninety-nine percent of all maternal deaths occur in resource-poor nations, averaging 800 deaths each day or 33 per hour. Improvement in maternal mortality was addressed by the United Nations in 1990 by the Millennium Development Goals (MDG's) in which the 5th goal was global reduction of this statistic by three-quarters by the year 2015. However, this goal will not be achieved. For every mother that dies from pregnancy in resource-poor countries, 15 to 30 additional women develop serious damage. This textbook addresses the continuing problem of maternal deaths in developing nations from three perspectives: medical, anthropological, and epidemiological. The twenty-eight internationally-respected authors in this textbook have had direct field experience with maternal health and pregnancy complications in resource-poor regions. They provide up-to-date analysis of maternal deaths in the regions of the world most affected by this public health problem. These locations include Asia, South America, andmost severely affected Africa" (publisher).

Order of authorship in the original publication: Schwartz, Avvad-Portari, Babál, et al....
"Design.—Case-based retrospective clinico-pathological analysis by a multinational group of 44 perinatal specialists from 12 countries of placental and autopsy pathology findings from 64 stillborns and 4 neonatal deaths having placentas testing positive for SARS-CoV-2 following delivery to mothers with COVID-19."

"Conclusions.—The pathology abnormalities composing SARS-CoV-2 placentitis cause widespread and severe placental destruction resulting in placental malperfusion and insufficiency. In these cases, intrauterine and perinatal death likely results directly from placental insufficiency and fetal hypoxic-ischemic injury. There was no evidence that SARS-CoV-2 involvement of the fetus had a role in causing these deaths."

https://doi.org/10.5858/arpa.2022-0029-SA

"Abstract:               Background: The Bacille Calmette–Guérin (BCG) vaccine against tuberculosis is the most widespread vaccine in the world. Discovered by French investigators Albert Calmette and Camille Guérin at the Pasteur Institute, itremains the only effective vaccine against tuberculosis infection. This report describes the recognition andidentification of a previously unknown French handwritten laboratory notebook prepared by Drs. Calmette and Camille Guérin recording their experiments performed during the development of the BCG vaccine.

Methods: The notebook was examined, translated into English, photographed and the experiments analyzed.

Results: The manuscript laboratory notebook consists of 69 leaves written in 2 hands, one of which corresponds to that of Albert Calmette. It contains details of experiments that were performed during the development of the BCG vaccine at the Pasteur Institute by Drs. Calmette and Guérin. These include experimental inoculations of rabbits and guinea pigs; descriptions of the pathology of skin lesions, inflammatory reactions, and organ pathology; and survival outcome. The experiments describe varying inoculative dosages of the bacteria, and different routes of administration including intraperitoneal and subcutaneous injections, and administration of bacilli in the ear. In those cases where the animal had died following inoculation of tubercle bacilli, necropsy was performed and the organs examined and the pathology findings described. Details of culture experiments and vaccine passage are listed.

Conclusions: This previously unknown notebook is a highly organized and detailed record of investigations using tuberculosis in animal experiments and microbiological culture to produce a safe and effective vaccine, first used in humans in 1921."