ARNOLD, Frances Hamilton
1 entries
|
Tuning the activity of an enzyme for unusual environments: Sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide.Proc. Nat. Acad. Sci. (U.S.A.), 90 (12) 5618-5622, 1993.Arnold introduced a biochemical molecule manipulating technique to mimic the process of natural selection in creating new enzymes adapted to a specific catalytic reaction. She directed evolution of subtilisin E to obtain an enzyme variant which was active in a highly unnatural (denaturing) environment. In 2018 Arnold received half of the Nobel Prize in Chemistry "for the directed evolution of enzymes." Subjects: NOBEL PRIZES › Nobel Prize in Chemistry (selected), WOMEN, Publications by › Years 1900 - 1999 |