An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: March 22, 2024

NAKAZATO, Hiroshi

1 entries
  • 13973

Polyadenylic acid sequences in the heterogeneous nuclear RNA and rapidly-labeled polyribosomal RNA of HeLa cells: Possible evidence for a precursor relationship.

Proc. Nat. Acad. Sci. (USA), 68, 1336-1340, 1971.

Edmonds discovered the poly-A tails on eukaryotic mRNA. The addition of a poly(A) tail to an RNA transcript, typically a messenger RNA (mRNA), is called polyadenylation.

Poly(A)polymerase was first identified in 1960 as an enzymatic activity in extracts made from cell nuclei that could polymerise ATP, but not ADP, into polyadenine. Although identified in many types of cells, this activity had no known function until 1971, when Edmonds found poly(A) sequences in mRNAs. The only function of these sequences was thought at first to be protection of the 3′ end of the RNA from nucleases, but later the specific roles of polyadenylation in nuclear export and translation were identified. The polymerases responsible for polyadenylation were first purified and characterized in the 1960s and 1970s, but the large number of accessory proteins that control this process were discovered only in the early 1990s. Digital facsimile from PubMedCentral at this link.



Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Synthesis