An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16031 entries, 14098 authors and 1944 subjects. Updated: October 9, 2024

GOLDSTEIN, Joseph Leonard

1 entries
  • 14241

Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase activity in human fibroblasts by lipoproteins.

Proc. Nat. Acad. Sci. (U.S.A.), 70, 2162-2166, 1973.

Goldstein and Brown discovered that human cells have low-density lipoprotein (LDL) receptors that remove cholesterol from the blood and that when LDL receptors are not present in sufficient numbers, individuals develop hypercholesterolemia and become at risk for cholesterol related diseases, notably coronary heart disease. Digital facsimile from PubMedCentral at this link.

In 1985 Brown and Goldstein shared the Nobel Prize in Physiology or Medicine “for their discoveries concerning the regulation of cholesterol metabolism.”

See Goldstein & Brown, "History of discovery: The LDL receptor," Arterioscler. Thromb. Vasc. Biol., 29,  2009, 431–438. Full text from PubMedCentral at this link.



Subjects: BIOCHEMISTRY › Metabolism, NOBEL PRIZES › Nobel Prize in Physiology or Medicine