Classic description of general paralysis. Calmeil’s work complements Bayle’s earlier delineation of general paralysis (No. 4795). Between the two of them they established the clinical picture of general paralysis of the insane, associating it with chronic inflammation of the brain. This was the first breakthrough in neuro-psychiatric research, and it gave psychiatry the spur to precise and systematic clinical, pathological, and statistical innovation on its own terms.