ZAMECNIK, Paul Charles
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Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide (tridecamer deoxyribonucleotide/hybridization competitor/hybridon).Proc. Nat. Acad. Sci. (USA), 75, 280-284, 1978.Zamecnick and Stephenson reported the first example of specific inhibition of gene expression by an oligonucleotide when they demonstrated that a short oligonucleotide inhibited Rous sarcoma virus replication in cell culture. This work on gene expression modulation led to antisense therapy, or antisense therapeutics. Digital facsimile from PubMedCentral at this link. Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Synthesis, Biotechnology, VIROLOGY › VIRUSES (by Family) › Retroviridae › Rous Sarcoma Virus (RSV) |