HOLLAND, Paul
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Transmissible agent in non-A, non-B hepatitis.Lancet,1, 459-463, 1978.The first paper recording the discovery of what was, eleven years later in 1989, named the hepatitis C virus (see No. 12653). Harvey Alter and colleagues inoculated the serum/plasma of 4 patients with non-A/non-B hepatitis into 5 chimps, and the chimps showed both biochemical and histological evidence of a typical hepatitis. The experiment was performed with a negative control. Order of authorship in the original paper: Alter, Purcell, Holland.... (Thanks to Juan Weiss for this reference and its interpretation.) Subjects: NOBEL PRIZES › Nobel Prize in Physiology or Medicine , VIROLOGY › VIRUSES (by Family) › Hepadnaviridae › Hepatitis C Virus |