Diaz de Isla, a Barcelonese surgeon, wrote of a disease “previously unknown, unseen and undescribed”, which appeared in Barcelona in 1493 and which was obviously syphilis. This is probably the earliest reference to the West Indian origin of syphilis (the writer believed that the disease originated in Haiti) and the book is the chief source of the opinions of those who believe in the American origin of syphilis. Text reproduced with German translation in Janus, 1901, 6, 653-55; 1902, 7, 31-40. Extensively discussed in No. 2430.

Digital facsimile from Bayerische StaatsBibliothek at this link.