Discovery of introns simultaneously with Roberts, Chow, Broker (No. 11043). Sharp's electron microscopist, Berget, visualized the introns in the electron microscope. James D. Watson took note of the profound significance of the discovery and invited both groups to present their data at the Cold Spring Harbor Symposium that year. This helped solidify the discovery by both groups as "simultaneous."

In 1993 Sharp shared the Nobel Prize in Physiology or Medicine  with Richard J. Roberts "for their discoveries of split genes."

Digital facsimile from PubMedCentral at this link.

(Thanks for Juan Weiss for this entry and its interpretation.)