ROSS, Elliot M.
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Resolution of some components of adenylate cyclase necessary for catalytic activity.J. biol. Chem. , 252, 6966-6969, 1977.Goodman shared the 1994 Nobel Prize in Physiology or Medicine with Martin Rodbell "for their discovery of G-proteins and the role of these proteins in signal transduction in cells." In this paper Goodman and Ross showed that a guanine nucleotide binding protein (a "G" protein) activates adenylate cyclase. They posited a system whereby a hormone receptor (adrenergic), interacts with guanine nucleotides (G proteins), and these in turn activate the enzyme adenylate cyclase, but they qualified this with a statement that "proof of function of each entity must await their purification." Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Receptors |
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Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme.J. biol. Chem. , 253, 6401-12, 1978.Gilman and colleagues showed that G proteins are in the cell membrane and are stimulated once a ligand (adrenaline) binds the adrenergic receptor. This system can then activate adenyl cyclase to form cyclic AMP. Digital facsimile from PubMedCentral at this link. Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Receptors |