An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: March 22, 2024

SHEEHAN, John Clark

1 entries
  • 12633

The total synthesis of penicillin V.

J. Amer. chem. Soc., 29, 1262-1263, 1957.

Sheehan and Henery-Logan reported the step by step synthesis of penicillin V (phenoxymethylpenicillin) and the cyclization of the beta lactam ring, key to creation of beta-lactam antibiotics.

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: PHARMACOLOGY › PHARMACEUTICALS › Antibiotics, PHARMACOLOGY › PHARMACEUTICALS › Antibiotics › Penicillin